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IPC

C12N15/13(2006-01-01)

C12N15/66(2006-01-01)

C07K16/24(2006-01-01)

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Application

2014126168/10, 2014-06-26

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Start date

2014-06-26

(22)

Actual filing date

2014-06-26

(45)

Published

2015-09-10

(72)

Inventor

Tjumentseva Marina AlekseevnaTikunova Nina ViktorovnaBabkina Irina NikolaevnaMatveev Andrej LeonidovichBajkov Ivan KonstantinovichKukharenko Ljudmila Aleksandrovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Khimicheskoj Biologii I Fundamental'Noj Meditsiny Sibirskogo Otdelenija Rossijskoj Akademii Nauk So Ran)

RECOMBINANT PLAZMID DNA pCL2h-1I1G PROVIDING SYNTHESIS OF POLYPEPTIDE WITH PROPERTIES OF LIGHT CHAIN OF HUMAN ANTIBODY AGAINST INTERLEUKIN-18, RECOMBINANT PLAZMID DNA pCH2g-1I1G PROVIDING SYNTHESIS OF POLYPEPTIDE WITH PROPERTIES OF HEAVY CHAIN OF HUMAN ANTIBODY AGAINST INTERLEUKIN-18 AND RECOMBINANT HUMAN ANTIBODY fh1I1G WITH ABILITY TO BIND INTERLEUKIN-18 Russian patent published in 2015 - IPC C12N15/13 C12N15/66 C07K16/24

Abstract RU 2562857 C1

FIELD: biotechnologies.

SUBSTANCE: recombinant plazmid DNAs pCL2h-1I1G and pCH2g-1I1G providing in eukaryotic cells the synthesis of light and heavy chains of human antibody fh1I1G, capable to bind interleukin-18; and also the antibody obtained from eukaryotic cells, transfected by such recombinant plazmid DNAs, are offered.

EFFECT: invention allows to obtain the antibody capable to bind with interleukin-18 and having properties of extracted full-size human antibody of the class IgG1 that can be applicable in therapy.

3 cl, 9 dwg, 6 ex

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RU 2 562 857 C1

Authors

Tjumentseva Marina Alekseevna

Tikunova Nina Viktorovna

Babkina Irina Nikolaevna

Matveev Andrej Leonidovich

Bajkov Ivan Konstantinovich

Kukharenko Ljudmila Aleksandrovna

Dates

2015-09-10—Published

2014-06-26—Filed