METHOD OF PREDICTION OF STABILITY LIMIT OF ANIMALS TO SEVERE HYPOXIA AFTER HYPOXIC PRECONDITIONING Russian patent published in 2015 - IPC A61B10/00 

FIELD: biotechnology.

SUBSTANCE: intact animals are tested in the behavioural model test of pre-stimulation inhibition of acoustic startle response, determining the relative value of reducing the amplitude of the individual response to intense sound signal (ISS). Then they are subjected to moderate hypoxic preconditioning. After that according to ISS value the amount of ISS the stability limit of the body to severe hypoxia (Tsec) is determined, using the previously revealed reference correlation dependence using the Pearson correlation analysis Tsec = f (ISS). For obtaining the least, ISS is determined in a similar manner preliminary in other intact animals of the same species. They are then subjected to a similar moderate hypoxic preconditioning. After that, the animals are placed in conditions of severe hypoxia, and the value of the stability limit to it is determined by the time of the onset of signs of the animal agony.

EFFECT: method enables to study the animals on the possible resistance to severe hypoxia after preconditioning influence, and to predict its efficiency with a high degree of certainty.

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