MICE WITH HUMANIZED UNIVERSAL LIGHT CHAIN Russian patent published in 2023 - IPC C12N15/85 A01K67/27 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to methods providing for the use of a mouse, which contains an insert of at least one not rearranged human V_H gene segment, at least one not rearranged human D_H gene segment, and at least one not rearranged human J_H gene segment, no more than one or no more than two rearranged V/J sequences of a human light chain, as well as a nucleotide sequence, which encodes ADAM6 functional protein of a mouse.

EFFECT: invention is effective for creation of a sequence of a heavy chain variable region and a sequence of a heavy chain variable domain of a human antibody.

21 cl, 24 dwg, 23 tbl, 9 ex