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(19)

(11)

2 787 781

(13)

(51)

IPC

C12N15/85(2006-01-01)

A01K67/27(2006-01-01)

(21) (22)

Application

2018126211, 2012-08-03

(24)

Start date

2012-08-03

(22)

Actual filing date

2012-08-03

(45)

Published

2023-01-12

(72)

Inventor

Makvirter, DzhonMakdonald, LinStivens, ShonDevis, SemyuelBakler, Devid, R.Khosiava, Karolina, A.Merfi, Endryu, Dzhej

(73)

Holder

Regeneron Farmasyutikalz, Ink.

MICE WITH HUMANIZED UNIVERSAL LIGHT CHAIN Russian patent published in 2023 - IPC C12N15/85 A01K67/27

Abstract RU 2787781 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to methods providing for the use of a mouse, which contains an insert of at least one not rearranged human V_H gene segment, at least one not rearranged human D_H gene segment, and at least one not rearranged human J_H gene segment, no more than one or no more than two rearranged V/J sequences of a human light chain, as well as a nucleotide sequence, which encodes ADAM6 functional protein of a mouse.

EFFECT: invention is effective for creation of a sequence of a heavy chain variable region and a sequence of a heavy chain variable domain of a human antibody.

21 cl, 24 dwg, 23 tbl, 9 ex

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RU 2 787 781 C2

Authors

Makvirter, Dzhon

Makdonald, Lin

Stivens, Shon

Devis, Semyuel

Bakler, Devid, R.

Khosiava, Karolina, A.

Merfi, Endryu, Dzhej

Dates

2023-01-12—Published

2012-08-03—Filed