FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a mouse containing in the genome of its germ line: humanised heavy chain immunoglobulin locus, a humanised light chain immunoglobulin locus and an ectopic nucleic acid sequence encoding a mouse ADAM6 functional protein or its functional ortholog, homologue or fragment. Also, the use of said mouse for the production of a variable region of a human immunoglobulin and for the selection of a variable region of a human immunoglobulin is disclosed.
EFFECT: invention makes it possible to efficiently obtain a variable region of a human immunoglobulin.
8 cl, 24 dwg, 23 tbl, 9 ex
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