METHOD FOR PRODUCTION OF SILICON-CONTAINING BIOMIMETIC CALCIUM-PHOSPHATE COATING ON TITANIUM ALLOYS FROM HUMAN INTERSTITIAL FLUID MODEL SOLUTIONS Russian patent published in 2017 - IPC A61L27/12 A61L27/32 C01B25/32 C04B35/447 

FIELD: pharmacology.

SUBSTANCE: method for production of a biomimetic silicon-containing calcium-phosphate coating on titanium alloys from a human intercellular fluid model solution is described, in which a solution of the following composition is preliminarily prepared: CaCl₂ - 3.7424 g, MgCl₂ - 0.6092 g, K₂HPO₄ - 2.8716 g, NaHCO₃ - 4.5360 g, Na₂SO₄ - 0.0144 g, NaCl- 8.8784 g, Na₂SiO₃ - 0.0488÷0.2444 g, the resulting solution is precipitated at: temperature T1=20÷25°C, pH value of 7.40±0.05 for 48 hours, then the precipitate is washed, filtered, dried at temperature T₂=80÷85°C for 5 hours, an aqueous suspension is prepared from the resulting silicon-containing calcium-phosphate powder at concentration C=1÷5 wt %, the suspension is applied on the titanium alloy by a capillary method, dried at temperature T₃=20÷25°C for 1 hour, then the said alloy is placed into the preliminarily obtained model solution of human intercellular liquid for 3 days, then it is removed from the solution and dried at temperature of T₄=20÷25°C for 24 hours.

EFFECT: production of silicon-substituted hydroxyapatite, while silicon plays an important role in the physiological processes of bone and cartilaginous tissue growth and restructuring.

3 dwg, 1 tbl