MICE THAT PRODUCE BINDING PROTEINS CONTAINING V DOMAINS Russian patent published in 2021 - IPC A01K67/27 C12N5/10 C12N15/85 C07K16/00 C07K16/46

Abstract RU 2750219 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to a mouse for producing an immunoglobulin chain, as well as to its cell. Also disclosed is a method for producing the above-mentioned genetically modified mouse containing in its germ line an endogenous immunoglobulin heavy chain locus modified to contain the germ-type kappa (κ) genomic sequence.

EFFECT: resulting mouse can be effectively used to produce a hybrid immunoglobulin binding protein that contains a variable human light chain domain that is functionally linked to the constant region of the heavy chain, to produce an antigen binding protein containing a hybrid immunoglobulin chain and a light chain, and to produce a bispecific antibody.

27 cl, 9 dwg, 5 tbl, 1 ex

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RU 2 750 219 C2

Authors

Macdonald Lynn

Stevens Sean

Gurer Cagan

Hosiawa Karolina A.

Murphy Andrew J.

Dates

2021-06-24—Published

2011-08-02—Filed