MULTIVALENT RECOMBINANT AVIAN HERPES VIRUSES AND VACCINES FOR IMMUNISATION OF BIRDS Russian patent published in 2022 - IPC C12N15/869 A61K39/17 A61K39/12 

FIELD: biotechnology.

SUBSTANCE: described is a recombinant avian herpes virus suitable for vaccination of birds against the Newcastle disease virus (NDV) and the infectious bursal disease virus (IBDV), containing (i) a recombinant nucleotide sequence encoding the F protein of the Newcastle disease virus or an immunogenic fragment thereof, under control of a Pec promoter, embedded in a non-encoding region of the viral genome, located between UL45 and UL46; and (ii) a recombinant nucleotide sequence encoding the VP2 protein of the infectious bursal disease virus or an immunogenic fragment thereof, under the control of an mCMV 1E1 promoter, embedded in the non-encoding region of the viral genome, located between UL44 and UL45. Presented is a multivalent vaccine against the Newcastle disease virus (NDV) and the infectious bursal disease virus (IBDV), including an effective immunising amount of said recombinant avian herpes virus. Also presented is a method for vaccination of poultry against NDV and IBDV, including introduction of the multivalent vaccine to said poultry. Also presented is a vaccination kit for immunising birds against the Newcastle disease virus (NDV) and the infectious bursal disease virus (IBDV), including the following components: the effective amount of the described vaccine and agent for introduction of said components to said birds.

EFFECT: creation of a recombinant avian herpes virus suitable for vaccinating birds.

10 cl, 8 dwg, 5 tbl