METHOD OF PRODUCING BIOMIMETIC CALCIUM-PHOSPHATE GELATIN-MODIFIED COATING ON TITANIUM ALLOYS FROM A MODEL SOLUTION OF HUMAN INTERCELLULAR FLUID Russian patent published in 2019 - IPC A61L27/12 A61L27/32 C01B25/32 C04B35/447 

FIELD: biochemistry.

SUBSTANCE: invention relates to creation of new biomedical materials. Method of producing a biomimetic calcium-phosphate gelatin-modified coating on titanium alloys from a model solution of human intercellular fluid involves preparing a solution of the following composition: CaCl₂ – 3.7424 g, MgCl₂ – 0.6092 g, K₂HPO₄ – 2.8716 g, NaHCO₃ – 4.5360 g, Na₂SO₄ – 0.0144 g, NaCl – 8.8784 g, gelatine – 4.9990–4.9970 g, obtained solution is deposited at temperature T₁ = 20–25 °C and pH = 7.40 ± 0.05 for 48 hours, then precipitate is washed, filtered, dried at temperature T₂ = 80–85 °C for 5 hours, from calcium-phosphate gelatin-modified powder an aqueous suspension is prepared at concentration C = 1 wt. %, suspension is applied by capillary method on titanium alloy (VT1-00), dried at temperature T₃ = 20–25 °C for 1 hour, then said alloy is lowered into the obtained pre-model solution of human intercellular fluid for 3 days, then removed from solution and dried at temperature T₄ = 20–25 °C for 24 hours.

EFFECT: invention increases adhesion and mechanical strength, high crystallinity.

2 cl, 6 dwg, 1 tbl, 1 ex