METHOD FOR PREPARING BIOMIMETIC CALCIUM-PHOSPHATE COATING ON TITANIUM ALLOYS FROM STANDARDISED TEST SOLUTION OF HUMAN SYNOVIAL FLUID Russian patent published in 2014 - IPC A61L27/12 A61L27/32 C04B35/447 C01B25/32 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and preparing new materials for biomedical applications, which can be used for preparing bioactive calcium-phosphate coatings of implants with preparing bi-phase composites of calcium phosphates and titanium alloys. What is declared is a method for preparing a biomimetic calcium-phosphate coating on titanium alloys from a standardised test solution of a human synovial fluid, wherein a solution of the following composition is prepared: CaCl₂ - 1.3431 g/l, Na₂HPO₄·12H₂O - 7.4822 g/l, NaCl - 2.8798 g/l, MgCl₂·6H₂O - 0.4764 g/l, Na₂SO₄ - 1.6188 g/l, KCl - 0.3427 g/l, NaHCO₃ - 2.0160 g/l; two solid phases of carbonate hydroxylapatite and octacalcium phosphate are precipitated at a temperature of 22-25°C, pH=7.4±0.05 for 7 days. That is followed by filtering and drying at 100°C for 2-3 hours to remove chemically unbound water, and an aqueous suspension in the calcium phosphate concentration of 5-10 wt % is prepared. The prepared suspension is applied by a capillary method on the titanium alloy and dried at a temperature of 20-25°C for 24 hours.

EFFECT: invention provides preparing the high-quality coating consisting of carbonate hydroxylapatite and octacalcium phosphate on the titanium alloys.

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