FIELD: pharmaceutics.
SUBSTANCE: present invention relates to 2-iminobiotine pharmaceutical aqueous composition, having pH from 3 to 7 and containing 1 mg/ml or more of 2-iminobiotine and from 2.5 to 40 % of substituted beta-cyclodextrin, wherein said substituted beta-cyclodextrin is selected from sulfobutylether-beta-cyclodextrin (SBE-CD) and hydroxypropyl-beta-cyclodextrin.
EFFECT: invention provides creation of aqueous solution of 2-iminobiotine with high content of 2-iminobiotine (higher solubility of 2-iminobiotine), which is ensured by introduction of substituted beta-cyclodextrin into disclosed composition or citric acid/citrate buffer to ensure solution pH from 3 to 7.
19 cl, 14 ex, 27 tbl, 1 dwg
| Title |
Year |
Author |
Number |
| FORMULATIONS OF INTRAVENOUS SOLUTIONS OF POSACONAZOLE STABILISED BY SUBSTITUTED BETA-CYCLODEXTRINE |
2011 |
- Khajmbekher S'Juzan K.
- Montehjt Dehvid
- Pipkin Dzhejms D.
|
RU2575768C2 |
| ANTIMICROBIAL PRESERVATIVES FOR OBTAINING MULTIDOZE COMPOUNDINGS USING β-CYCLODEXTRINES FOR LIQUID MEDICINAL FORMS |
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- Adami Rodzher Kristofer
- David Frederik
- Vud Dzhulija Ehnn
|
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- Pipkin Dzhejms D.
- Tsimmerer Rupert O.
- Tompson Dajan O.
- Mosher Dzherol'D L.
|
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- Radzhkhavan Krishnasvami S.
- Mehlloi Timoti M.
- Vehria Sehjlesh A.
|
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| INHALATION COMPOSITION CONTAINING SULFOALKYL ETHER |
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- Pipkin Dzhejms D.
- Tsimmerer Rupert O.
- Tompson Dajan O.
- Mosher Dzherol'D L.
|
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- Hird, Geoffrey S.
- Bommareddy, Ganesh S.P.
- Joshi, Anjali
- Mcshane, James
|
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| COMPOSITIONS CONTAINING ACETAMINOPHENE AND CYCLODEXTRIN SULFAOKYL ETHER |
2017 |
- Rajevski, Rodzher
- Pipkin, Dzhejms, D.
- Mosher, Dzherold, L.
|
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| SUSTAINED-RELEASE DELIVERY COMPOSITION AND A METHOD FOR STABILIZING PROTEINS IN THE MANUFACTURING PROCESS |
2014 |
|
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- Nerurkar Manodzh
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- Dominik Mark
|
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| SOLID PHARMACEUTICAL PREPARATIVE FORMULATIONS WITH CONTROLLED RELEASE BASED ON CYCLODEXTRIN SULFOALKYL ESTERS |
2000 |
- Stella Valentino Dzh.
- Radzhevski Rodzher A.
- Rao Venkatramana M.
- Makginiti Dzhejms V.
- Mosher Gerol'D L.
|
RU2233176C9 |
