METHOD FOR DETERMINATION OF PRESSURE IN TUMOUR Russian patent published in 2017 - IPC A61B5/55 A61K49/18 B82Y5/00 B82Y35/00 

FIELD: medicine.

SUBSTANCE: invention is intended to determine the pressure in tumours, which can be used to optimize the regimens of chemotherapy aimed at increased effectiveness of treatment, selection of a therapeutic agent or a combination thereof, adjusted dosage of the prescribed drugs, and optimised time of administration during the day. The mean radius of the tumour (ΔL) is measured, control drug represented by magneto-contrast nanoparticles are introduced in the tumor at a concentration sufficient for detection using MRI. Then, the MR signal is measured during control drug removal from the tumour, and the dependence of the change in the MR signal intensity in the tumour on time is plotted. Next, the target drug is introduced into the tumour, which is nanoparticles used in the control drug, covalently crosslinked with a protein with lectin properties, after the time necessary to remove the control drug from the body. Then, the MR signal is measured during target drug removal from the tumour, and the dependence of the change in the MR signal intensity in the tumour on time is plotted. The obtained dependences determine the delay time Δt of the target drug removal from the tumour relative to the control drug with subsequent calculation of the tumour pressure according to the appropriate formula.

EFFECT: method provides an objective and non-invasive pressure measurement in the tumour, including several tumour sites.

8 cl, 1 dwg, 2 ex