TISSUE-ENGINEERING BIODEGRADABLE VASCULAR IMPLANT Russian patent published in 2018 - IPC A61F2/06 A61L27/14 A61L27/54 

FIELD: medicine.

SUBSTANCE: made of biodegradable polymers by electrospinning with layer-by-layer introduction of biologically active molecules into the vascular wall: vascular endothelial growth factor (VEGF), fibroblast growth factor (bFGF) and chemoattractant molecule (SDF-1α). The polymer composition is a mixture of polyhydroxybutyrate-valerate and polycaprolactone (PGBV/PCL), taken in the ratio of 1:2. Electrospinning is performed with the participation of a solution containing a polymer composition with VEGF molecules, and then a solution of polymers with an aqueous fraction of biologically active molecules - bFGF and SDF-1α. The invention can be used in cardiovascular surgery for reconstructive operations on vessels.

EFFECT: tissue-engineering graft fabricated by this method corresponds to the layered structure of the vessel wall of a living organism while preserving the vitality and functional activity of biologically active components before the degradation of the polymer matrix.

3 cl, 1 tbl, 2 ex