ANTIGEN-BINDING MOLECULE, ABLE TO MULTIPLELY CONTACT WITH PLURALITY OF ANTIGENIC MOLECULES Russian patent published in 2018 - IPC C12N15/09 C07K16/00 C07K19/00 C12N15/62 G01N33/53 C07K14/705 

FIELD: biotechnology.

SUBSTANCE: molecule containing a human antigen-binding domain and a FcRn-binding domain with antigen-binding activity different in two different conditions of calcium concentration and lower in conditions of low calcium concentrations compared to the conditions of high calcium concentration, where the low calcium concentration represents the concentration of ionized calcium of 0.1 to 30 mcm, and the high calcium concentration is ionized calcium concentration of 100 mcm to 10 mm, where the specified antibody contains at least four amino acids selected from the group consisting of amino acids at positions 30, 31, 32, 50 and 92, in accordance with the numbering along the Kabat light chain, with chelant activity against metal. Also, a pharmaceutical composition comprising the antibody is described. The invention can be used to accelerate the capture of the antigen by antigen-binding molecules into cells, increase the number of times of antigen binding by one molecule, accelerate the reduction of antigen concentration in plasma and increase the retention of an antigen-binding molecules in the plasma, as well as antigen-binding molecules.

EFFECT: decreased antigen concentration in plasma.

5 cl, 56 dwg, 28 tbl, 25 ex