FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a method for screening of a candidate agent for a capability of modulating the development and/or activity of hematopoietic cells. The method provides for the use of an immune-deficiency mouse that is grafted with human hematopoietic cells and contains nucleic acid encoding human IL-6, where nucleic acid encoding human IL-6 is functionally connected to a mouse IL-6 promotor in a mouse locus.
EFFECT: invention is effective for screening of a candidate agent for a capability of modulating the development and/or activity of hematopoietic cells.
18 cl, 15 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS FOR USE THEREOF | 2013 |
|
RU2673156C2 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHOD FOR THEIR APPLICATION | 2013 |
|
RU2642319C2 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHOD FOR THEIR USE | 2013 |
|
RU2768282C2 |
| NON-HUMAN GENETICALLY MODIFIED ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2711744C1 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2799086C2 |
| HUMANISED MOUSE M-CSF | 2012 |
|
RU2577978C2 |
| HUMANISED M-CSF MICE | 2012 |
|
RU2730643C2 |
| HUMANIZED M-CSF MICE | 2020 |
|
RU2819731C2 |
| HUMANISED MICE WITH SIRPA-IL15 NOKIN AND METHODS FOR USING THEM | 2016 |
|
RU2730599C2 |
| HUMANISED IL-15 ANIMALS | 2014 |
|
RU2674910C2 |
