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(19)

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2 730 643

(13)

(51)

IPC

A01K67/27(2006-01-01)

C12N15/09(2006-01-01)

C12N15/06(2006-01-01)

C12N15/19(2006-01-01)

C12N15/85(2006-01-01)

G01N33/50(2006-01-01)

(21) (22)

Application

2016104468, 2012-02-14

(24)

Start date

2012-02-14

(22)

Actual filing date

2012-02-14

(45)

Published

2020-08-24

(72)

Inventor

Merfi Endryu Dzh.Stivens ShonRatinam ChozhavendanEjnon ElizabetMants MarkusFlavell RichardYankopulos Dzhordzh D.

(73)

Holder

Ridzheneron Farmasyutikalz, Ink.Jel YuniversitiInstityut For Riserch In Bajomedsin

HUMANISED M-CSF MICE Russian patent published in 2020 - IPC A01K67/27 C12N15/09 C12N15/06 C12N15/19 C12N15/85 G01N33/50

Abstract RU 2730643 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to a humanised mouse which contains a nucleic acid sequence encoding a human protein M-CSF and operably linked to an endogenous promoter of a mouse M-CSF gene in a mouse M-CSF locus, as well as methods for producing it. Also disclosed are methods of screening substance for presence of activity, modulating function of human hematopoietic cells in humanized M-CSF mouse, using above described mouse.

EFFECT: invention enables efficient production of humanised mice expressing human protein M-CSF in bone marrow, spleen, blood, liver, brain, lungs, testis and kidney.

55 cl, 9 dwg, 4 ex

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RU 2 730 643 C2

Authors

Merfi Endryu Dzh.

Stivens Shon

Ratinam Chozhavendan

Ejnon Elizabet

Mants Markus

Flavell Richard

Yankopulos Dzhordzh D.

Dates

2020-08-24—Published

2012-02-14—Filed