METHOD OF PROPHYLAXIS OF ACUTE INTESTINAL DISEASES IN CALVES Russian patent published in 2018 - IPC A61K39/09 A61K39/108 A61K39/116 A61P1/00 

FIELD: veterinary.

SUBSTANCE: invention relates to veterinary medicine and can be used for prevention of acute intestinal diseases of calves. Method for prevention of acute intestinal diseases of calves, including a two-fold immunization of the infertile cows 30 days before calving in a dose of 5.0 ml/head. subcutaneously in the upper third of the neck and calves vaccine. Vaccine contains a mixture of formalin-inactivated antigens, which use a cell-free culture medium, which is obtained by sterilizing filtration of broth culture of Escherichia coli, producing thermolabile, thermostable and shiga-like toxins, as well as culture media containing cells of hemolytic strains Streptococcus bovis and Enterococcus faecalis. Mix them with the following ratio of components, mass%: culture medium containing cells of hemolytic strains Streptococcus bovis 26.0–30.0; culture medium containing cells of hemolytic strains Enterococcus faecalis 26.0–30.0; cell-free culture medium containing toxins of Escherichia coli is the rest. At the same time, additional immunization of the pregnant cows is carried out 15 days before calving in a dose of 10.0 ml/head and calves are immunized at the age of 15–20 days in a dose of 1.0 ml/head and second time in 10–14 days in a dose of 2 ml/head.

EFFECT: use of a vaccine containing this ratio of culture media provides high protective activity, protecting calves from acute intestinal diseases caused by pathogenic Escherichia coli, Streptococcus bovis and Enterococcus faecalis.

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