HYDROXIDE ALUMINUM OIL VACCINE AGAINST ESCHERICHIOSIS IN CALVES AND PIGLETS Russian patent published in 2023 - IPC A61K39/108 A61K39/39 C12N1/20 A61P31/04 

FIELD: biotechnology.

SUBSTANCE: vaccine against escherichiosis of calves and piglets is proposed, the said vaccine includes a cell-free culture medium containing inactivated heat-labile, heat-stable and Shiga-like toxins of Escherichia coli obtained by mixing equal proportions of epizootic Escherichia coli strains with genes for heat-labile, heat-stable and Shiga-like toxins inactivated by formalin to its final concentration of 0.4%, followed by separation of the bacterial mass using sterilizing filtration and adjuvants, while as adjuvants it contains a 2% suspension of Al (OH)₃ and an oil adjuvant consisting of an emulsifier used as a biologically inert organosilicon compound cetyl-PEG/PPG-10/1-dimethicone in the amount of 1.5% and the oil base — vaccine oil "M" — 98.5%, which are introduced into the cell-free culture medium in turn, followed by mixing, in the following ratio of components, wt.% : 2% suspension of Al(OH)₃ 19-21; oil adjuvant 49-51; cell-free culture medium containing inactivated thermolabile, thermostable and Shiga-like toxins of Escherichia coli up to 100.

EFFECT: invention provides the expansion of the arsenal of vaccine preparations for the prevention of escherichiosis in animals.

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