FIELD: medicine.
SUBSTANCE: invention relates to medicine and is intended for early diagnosis of acute infective endocarditis (IE). Venous blood samples are taken, isolation of genomic DNA, allele-specific polymerase chain reaction and genotyping of polymorphic locus -455G-A of FGB gene in persons at risk. Carriers of the genotype -455A-A diagnose acute IE with a 13.09-fold risk of its development.
EFFECT: invention makes it possible to differentiate acute IE from sepsis on the basis of genetically determined predisposition to IE in Russian men, carriers of genotype -455A-A of the FGB gene.
1 cl, 2 dwg, 2 tbl, 3 ex
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