METHOD FOR PREDICTING ACUTE RENAL AND HEPATIC INSUFFICIENCY Russian patent published in 2018 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery, and can be used to predict the development of acute renal-hepatic insufficiency in patients with acute surgical pathology. Essence of the method: in patients with acute surgical abdominal pathology daily, starting from the first day after surgical treatment, in dynamics, the content of molecules of medium mass, creatinine, bilirubin and malonic dialdehyde is determined in venous blood, on the basis of which the index of prognosis for acute renal and hepatic insufficiency (IP ARHI) is calculated according to the formula: $$\text{IP ARHI}=\text{(MSM}+\frac{{\text{K}}_{\text{2}}}{{\text{K}}_{\text{1}}}+\frac{{\text{B}}_{\text{2}}}{{\text{B}}_{\text{1}}}\text{)}\cdot \frac{{\text{MDA}}_{\text{2}}}{\text{MDA}{}_{\text{1}}},$$ where the MSM₂ – content of molecules of medium mass at the current moment, MSM₁ – content of molecules of medium mass at the previous moment, K₂ – content of creatinine at the current time, K₁ – content of creatinine at the previous time, B₂ – content of bilirubin at the current moment, B₁ – content of bilirubin at the previous moment, MDA₂ – content of malonic dialdehyde at the current moment, MDA₁ – content of malonic dialdehyde at the previous moment. Value of the prognostic index of the ARHI less than 3.34 states that there is no probability of developing acute renal and hepatic insufficiency, from 3.35 to 4.19 suggests a low probability of progression of ARHI, from 4.20 or more suggests a high probability of progression of ARHI.

EFFECT: invention improves accuracy of predicting ARHI and its adequate assessment of severity by establishing the severity of membrane-destructive phenomena, which allows for timely measures to correct therapy.

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