SEPARATION MATERIAL COMPRISING PHOSPHORYL CHOLINE DERIVATIVES Russian patent published in 2018 - IPC C07F9/09 A61K31/661 A61M1/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), a separation material of formula (II), a column for extracorporeal removal of the C-reactive protein (CRP), and a device comprising same, which can be used in medicine: (I), (II), where b selected from 2 and 3; X selected from -SH, -NH₂, -C≡CH, -CH=CH₂, -N₃ and -CHO; R¹ and R² selected from -CH₃, -C₂H₅, -C₃H₇, -C₄H₉, -C₅H₁₁ and -C₆H₁₃, or R¹ and R² form, together with the nitrogen atom to which they are attached, a heterocycle selected from: , and , where the hydrogen atoms can be replaced by fluorine atoms; -L- in formula (I) selected from -(CH₂)_m-O-C(O)-NH-(CH₂)_p1-, -(CH₂)_m-O-(CH₂)_p1-, -(CH₂)_m-C(O)-NH-(CH₂)_p1-, -(CH₂)_m-NH-C(O)-(CH₂)_p1-, -(CH₂)_m-C(O)-NH-(CH₂)_n-O-(CH₂)_p1-, -(CH₂)_m-O-C(O)-NH-(CH₂)_n-O-(CH₂)_p1-, -(CH₂)_m-C(O)-NH-(CH₂)_n-C(O)-NH-(CH₂)_p1-O-(CH₂)_p2-, and -(CH₂)_m-O-C(O)-NH-(CH₂)_n-C(O)-NH-(CH₂)_p1-O-(CH₂)_p2-; m, n, p1, p2, o, r, q selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10; Y selected from -CH(OH)-CH₂-NH-, -CH(OH)-CH₂-S-, -CH₂-NH-, -NH-CH₂-, -CH₂-CH₂-S-, -S-CH₂-CH₂-, , , , , , , and ; -L- in formula (II) selected from -L^a-, -L^a-L^e-, -L^a-L^b-L^e- and -L^a-L^b-L^d-L^c-L^e-, where -L^a- selected from -(CH₂)_m-, -(CH₂-CH₂-O)_m-CH₂-; -L^b- and -L^c- selected from -O-, -NH-C(O)-, -C(O)- NH-, -O-C(O)- NH- and -SO₂-; -L^d- selected from -(CH₂)_n-, -(CH₂-CH₂-O)_n-CH₂-; -L^e- selected from -(CH₂)_p1-, -(CH₂)_p1-O-(CH₂)_p2-; -L*- selected from -L*^a-, -L*^a-L*^e- and -L*^a-L*^b-L*^e-, where -L*^a- selected from -(CH₂)_o-, -(CH₂-CH₂-O)_o-C₂H₄-, -(CH₂-CH₂-O)_o-CH₂- and -CH₂-CH(OH)-CH₂-; -L*^e- selected from -(CH₂)_q-, -C₂H₄-(O-CH₂-CH₂)_q-, and CH₂-(O-CH₂-CH₂)_q-; -L*^b- selected from -O-(CH₂)_r-O-, -S-(CH₂)_r-S-, -SO₂-, -S-, -O-, -NH-C(O)-, -C(O)-NH- and -S-S-; and A is a solid substrate of agarose and sepharose^®.

EFFECT: novel compound, a novel separation material, a novel column and a device comprising same are disclosed for effective extracorporeal removal of CRP from a biological fluid for the prevention or treatment of immune dysfunctions and cardiovascular diseases.

9 cl, 27 ex, 1 tbl