FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a genetically modified rodent animal expressing a humanized Baff protein, as well as a method for its preparation. Genome of the above genetically modified rodent animal comprises replacing the genomic fragment of the endogenous Baff rodent gene with a human genomic fragment containing the exons of the 3–6 human BAFF gene to form a humanized Baff gene. Embryonic stem cell as well as the embryo of the above rodent are also disclosed. Invention also relates to a method for transplanting human cells to the aforementioned rodent.
EFFECT: invention makes it possible to efficiently obtain a rodent animal expressing a humanized Baff protein.
13 cl, 2 dwg, 4 tbl, 1 ex
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