NON-HUMAN ANIMALS HAVING A HUMANIZED PROLIFERATION-INDUCING LIGAND GENE Russian patent published in 2018 - IPC C07K14/705 A01K67/27 C12N15/85 

Abstract RU 2671101 C1

FIELD: biochemistry.

SUBSTANCE: invention relates to the field of biochemistry, in particular to a genetically modified rodent animal expressing the humanized April protein, as well as to a method for its production. Genome of the above genetically modified rodent animal comprises replacing the genomic fragment of the endogenous gene of the proliferation-inducing ligand (April) of the rodent with a human genomic fragment containing the exons of the 2-6 human APRIL gene. Embryonic stem cell as well as the embryo of the above rodent are also disclosed. Invention also relates to a method for transplanting human cells to the aforementioned rodent.

EFFECT: invention makes it possible to efficiently obtain a rodent expressing the humanized protein April.

13 cl, 4 dwg, 4 tbl, 2 ex

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RU 2 671 101 C1

Authors

Mcwhirter John

Gurer Cagan

Macdonald Lynn

Murphy Andrew J.

Dates

2018-10-29Published

2014-11-10Filed