FIELD: biotechnology.
SUBSTANCE: group of inventions refers to the biotechnology industry, in particular to the equipment used to create and support biological reactions of any purpose. Disposable bioreactor vessel comprises a bioreactor bag wall having an inner side and an outer side and a single opening extending from the inner side to the outside; the inner side is configured to contact the reaction mixture and its containment, a port installed in the opening. Port includes a flange fixedly attached to the bioreactor bag so as to maintain a fluid seal along the circumference of the flange, and a first sensor configured to recognize the parameter of the first process and located within the port and a second sensor configured to recognize the parameter of the second process. Second sensor is also located inside the port in such a way that the port supports the first and second sensors inside a single hole in the wall of the bioreactor bag. In this case, at least one sensor is configured to recognize a parameter selected from the group consisting of pH, concentration of the reaction mixture, dissolved oxygen concentration, conductivity, temperature and pressure. Method of manufacturing a disposable reaction vessel comprises forming a reaction chamber having a wall with a single opening therein; sealed attachment of the port to a single opening of the reaction chamber; and connecting the first and second sensors to the reaction chamber via a port in such a way that each of the first and second sensors passes through the port and through the wall and comes into contact with the reaction mixture inside the reaction chamber.
EFFECT: group of inventions provides an increase in the convenience of operating a disposable bioreactor vessel while reducing material costs.
18 cl, 8 dwg
Title | Year | Author | Number |
---|---|---|---|
POLYMERIC SYSTEM WITH OFFSET SEALING FOR DISPOSABLE CONTAINER | 2016 |
|
RU2672455C1 |
ASSEMBLY UNITS OF PERFUSION BIOREACTOR BAGS | 2017 |
|
RU2755725C2 |
INDEX SENSOR OF pH FOR SINGLE USE EQUIPMENT | 2016 |
|
RU2667694C1 |
SINGLE-USE PH SENSOR FOR BIORECATOR APPLICATIONS | 2019 |
|
RU2752474C1 |
INDUSTRIAL SOLID-PHASE BIOREACTOR, INDUSTRIAL SOLID-PHASE BIOREACTOR SYSTEM | 2013 |
|
RU2603754C2 |
INTERFACE OF A REMOVABLE DISSOLVED OXYGEN SENSOR FOR A DISPOSABLE BIOREACTOR/MIXER | 2019 |
|
RU2756382C1 |
ASYMMETRIC CONICAL BIOREACTOR SYSTEM AND METHOD FOR ITS USE | 2021 |
|
RU2797021C1 |
BIOPROCESSING SYSTEMS AND METHODS | 2019 |
|
RU2793734C2 |
HEAT EXCHANGE MODULE FOR USE IN CHEMICAL, PHARMACEUTICAL OR BIOLOGICAL REACTOR SYSTEM | 2013 |
|
RU2606011C2 |
BIOREACTOR WITH CONSTRUCTIVE SOLUTION, INCLUDING MULTIPLE OR POSITION-ADJUSTABLE AGITATORS | 2014 |
|
RU2704229C2 |
Authors
Dates
2018-10-18—Published
2016-03-30—Filed