FIELD: bioprocessing systems and methods.
SUBSTANCE: group of inventions relates more specifically to a bioprocessing system and method for providing cellular immunotherapy. The bioprocessing system includes a first module for enriching and isolating the cell population, a second module for activating, genetically modifying and expanding the cell population, and a third module for harvesting the expanded cell population. Moreover, each module is closed. The method of bioprocessing for cell therapy includes the enrichment and selection of a population of cells in the first module; activating, genetically modifying, and propagating the cell population in a second module; and harvesting the proliferated cell population in a third module.
EFFECT: implementation of the group of inventions makes it possible to reduce the risk of contamination by increasing automation and reducing manual processing.
16 cl, 82 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| ASSEMBLY UNITS OF PERFUSION BIOREACTOR BAGS | 2017 |
|
RU2755725C2 |
| SYSTEM AND METHOD FOR PARTICLE FILTRATION | 2010 |
|
RU2539989C2 |
| METHOD FOR DETACHABLE-TOPPING FERMENTATION WITH HIGH CELL DENSITY | 2015 |
|
RU2710967C2 |
| DEVICE, SYSTEM AND METHOD FOR AUTOMATED SAMPLE TRANSFER | 2015 |
|
RU2693657C2 |
| PERFUSION BIOREACTOR WITH FILTRATION SYSTEMS | 2019 |
|
RU2795881C2 |
| METHODS FOR CREATION OF HIGH DENSITY CELL BANK (VARIANTS) | 2014 |
|
RU2668796C2 |
| METHODS FOR CREATION OF CELLS BANKS WITH ULTRAHIGH DENSITY | 2015 |
|
RU2723129C2 |
| METHOD AND BIOREACTOR OF CULTIVATION AND STIMULATION OF THREE-DIMENSIONAL VIABLE CELL TRANSPLANTS RESISTANT TO MECHANICAL LOAD | 2004 |
|
RU2370534C2 |
| MICRODEVICE FOR CELL CULTURE | 2020 |
|
RU2809541C1 |
| HEAT EXCHANGE MODULE FOR USE IN CHEMICAL, PHARMACEUTICAL OR BIOLOGICAL REACTOR SYSTEM | 2013 |
|
RU2606011C2 |
