VACCINE FOR INTRAUTERINE DISEASE Russian patent published in 2018 - IPC A61K39/02 A61K39/108 A61K39/114 A61K35/74 A61P15/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the protection of the health of ruminants and, more particularly, to compositions and methods which enable to reduce the effect of bacterial infections associated with intrauterine disease. Method for prophylaxis of puerperal metritis and improving reproductive function of ruminants includes subcutaneously administering a veterinary composition to the ruminant mammal, the veterinary composition comprising inactivated whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes) and Fusobacterium necrophorum (F. necrophorum) or F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin with His-tag (His-FimH) and T. pyogenes pyolysin with His-tag (His-PLO) or a combination of said proteins and whole cells, and an adjuvant, which is aluminium hydroxide. Veterinary compositions and kits for carrying out said methods are also disclosed.

EFFECT: group of inventions provides reduction in the incidence rate of puerperal metritis, as well as improved reproductive function in the ruminant by subcutaneous administration of the veterinary composition.

28 cl, 5 dwg, 8 tbl, 2 ex