METHODS AND SYSTEMS FOR IDENTIFYING AND TREATING ANTI-PROGESTIN SENSITIVE TUMOURS Russian patent published in 2018 - IPC A61K31/58 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and can be used to suppress the growth of a tumour susceptible to growth inhibition by anti-progestins. To do this end, a sample of the patient's tissue, which presumably is oncogenic or cancerous, is obtained. Progesterone receptor-positive (PR-positive) cells are detected in the tissue sample. Degree of spread of progesterone receptor foci in the nuclei of progesterone-positive cells present in said tissue sample is determined. Onapristone antiprogestin is administered to the patient if there are clearly expressed progesterone receptor foci in said tissue sample that exceed 5 % of the number of PR-positive cells. Methods are also disclosed for treating a patient with a tumour susceptible to growth inhibition by anti-progestins, or who presumably has a tumour susceptible to growth inhibition by onapristone, and a system for classifying the tumour as susceptible to onapristone treatment.

EFFECT: group of inventions provides treatment of a patient with a tumour susceptible to growth inhibition by onapristone.

17 cl, 11 tbl, 4 dwg, 6 dwg