METHOD OF DIAGNOSTICS OF RECURRENT BRONCHITIS ASSOCIATED WITH THE IMPACT OF FINE DUST IN CHILDREN Russian patent published in 2018 - IPC A61B5/00 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pulmonology and toxicology. On the territory of the average daily content of fine dust, 1.6 or more times the maximum permissible concentration, children with recurrent bronchitis are detected. Functional characteristics of the child are determined: the respiratory impedance Zrs and its resistive resistance Rrs and the reactance Xrs in the frequency range of 5–35 Hz, as well as the index of the resonant frequency Fr. As laboratory parameters set: the content of lymphocytes; eosinophilic lymphocytic index; the content of CD 19+ and CD56+ lymphocytes; the level of blood serum antioxidant activity (AO A); malondialdehyde (MDA) level; lipid hydroperoxide level; superoxide dismutase level (Cu/Zn-SOD); the content of immunoglobulin A (IgA) and the content of immunoglobulin E (IgE); phagocytosis indicators: phagocytic number, phagocytic index. With an increase, compared with the norm, the respiratory impedance Zrs, with a decrease in the reactance Xrs by not less than 15 % and an increase in the resistive resistance Rrs by not less than 20 %, with an increase in the resonant frequency Fr, as well as when exceeding the norm: the content of CD 19+ lymphocytes by 15 % or more; eosinophilic lymphocytic index 2.0 times or more; the level of MDA in 1.5 times or more; the lipid hydroperoxide level in 1.2 times or more; IgA content of at least 15 %; the content of IgE more than 1.5 times; phagocytic number and phagocytic index of more than 1.2 times; and a decrease relative to the age physiological norm: the content of lymphocytes in 1.3 times or more; the content of CD56+ lymphocytes by 15 % or more; AOA level not less than 1.5 times; the level of Cu/Zn-SOD at least 1.2 times, recurrent bronchitis associated with exposure to fine dust is diagnosed in a child.

EFFECT: method allows informatively and conclusively diagnosing recurrent bronchitis associated with exposure to fine dust to prescribe adequate therapy in the early stages of the disease and prevent the development of complications by evaluating a set of the most significant indicators.

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