FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology. Proposed is an Escherichia sp. microorganism having L-tryptophan production capability, where the activities of endogenous 6-phospho-gluconate dehydratase (Edd) and 2-keto-3-deoxy-6-phospho-gluconate aldolase (Eda) are weakened or inactivated, where the microorganism has an enhanced PPP (pentose phosphate path) by means of a weak or blocked Entner-Dudoroff path. Proposed is a method for obtaining L-tryptophan using the specified microorganism.
EFFECT: group of inventions allows to increase the production of L-tryptophan compared to the parent unmodified microorganism.
6 cl, 5 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCTION OF L-AMINO ACID | 2003 |
|
RU2307165C2 |
| ESCHERICHIA GENUS MICROORGANISM HAVING L-TRYPTOPHAN PRODUCTIVITY, AND METHOD FOR PREPARING L-TRYPTOPHAN BY USING SAME | 2016 |
|
RU2711981C2 |
| ESCHERICHIA GENUS MICROORGANISM PRODUCING L-TRYPTOPHAN, AND METHOD OF PRODUCING L-TRYPTOPHAN USING THEREOF | 2016 |
|
RU2692645C2 |
| MICROORGANISM OF GENUS Escherichia, HAVING ENHANCED ABILITY TO PRODUCE L-TRYPTOPHAN, AND METHOD OF PRODUCING L-TRYPTOPHAN USING SAME | 2013 |
|
RU2593957C2 |
| NEW EXPORTER OF L-TRYPTOPHAN AND METHOD FOR PRODUCING L-TRYPTOPHAN USING SAID EXPORTER | 2019 |
|
RU2761871C1 |
| L-AMINO ACID PRODUCING MICROORGANISM AND METHOD FOR PRODUCING L-AMINO ACID WITH ITS USE | 2020 |
|
RU2795161C1 |
| NEW VARIANT OF AN L-TRYPTOPHAN EXPORTING PROTEIN AND METHOD FOR PRODUCING L-TRYPTOPHAN WITH APPLICATION THEREOF | 2020 |
|
RU2763603C1 |
| MICROORGANISM ABLE TO PRODUCE L-AMINO ACID AND METHOD FOR PRODUCING L-AMINO ACID BY USING SAME | 2013 |
|
RU2600875C2 |
| MICROORGANISM HAVING IMPROVED LEVEL OF INTRACELLULAR ENERGY, AND METHOD FOR PRODUCING L-AMINO ACID USING THEREOF | 2015 |
|
RU2700384C2 |
| METHOD OF PRODUCING L-TRYPTOPHAN BY ENHANCING PREPHENATE DEHYDRATASE ACTIVITY | 2021 |
|
RU2814875C1 |
