METHOD OF PRODUCING L-TRYPTOPHAN BY ENHANCING PREPHENATE DEHYDRATASE ACTIVITY Russian patent published in 2024 - IPC C12N1/21 C12N15/77 C12N9/88 C12P13/22 

Abstract RU 2814875 C1

FIELD: biotechnology.

SUBSTANCE: disclosed is a microorganism having an increased ability to produce L-tryptophan compared to a wild-type microorganism and having an enhanced prephenate dehydratase activity compared to endogenous activity, where said enhanced activity is obtained by increasing the number of copies of the gene coding prephenate dehydratase, or replacing the promoter of said gene with a strong promoter. Also disclosed is a method of producing L-tryptophan, comprising culturing said microorganism, a composition for producing L-tryptophan containing said microorganism, using said microorganism to produce L-tryptophan.

EFFECT: invention enables to obtain L-tryptophan with high output.

8 cl, 1 dwg, 6 tbl, 3 ex

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RU 2 814 875 C1

Authors

Seo Chang Il

Kim Hyun Ah

Son Sung Kwang

Cheong Ki Yong

Jung Moo Young

Kim Tae Yeon

Dates

2024-03-05Published

2021-03-05Filed