METHOD FOR DETERMINING SURVIVAL IN PATIENTS WITH PROXIMAL BILE DUCT TUMORS DURING PREOPERATIVE STAGE Russian patent published in 2019 - IPC A61B6/03 A61B5/55 G01N33/53 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, hepatobiliary surgery and oncology. To determine the long-term survival in patients with tumors of the proximal bile duct in the preoperative period in patients with tumors of the proximal bile duct in the preoperative period, the determination of diagnostic factors is carried out, clinical factors, morphological and molecular parameters of the tumor in the biological material obtained using biopsy are used. Used clinical factors are the stage of the tumor according to TNM, the damage to the lymph nodes of the hepatoduodenal ligament (HDL) according to CT and MRI, the degree of cell differentiation is used as morphological and molecular parameters, along with the level and presence of expression of N-kadherin, COX-2, the data obtained are assigned score points: when detecting stage I-II of the tumor, the TNM assigns 2 points, stage III-IV – 4 points; when a lesion is detected, the lymph nodes are assigned 1 point, in the absence of lesion – 0 points; when a high degree of differentiation is detected, the cells are assigned – 0 points, moderate – 2 points, low – 4 points, in the absence of N-cadherin expression – 0 points, in the presence of – 2 points, in the absence of COX-2 expression – 0 points, when identifying the expression level of 1 point, assign 3 points, 2 points – 4 points, 3 points – 6 points. Prognostic survival criterion P in patients with portal cholangiocarcinoma in the preoperative period is determined by the formula: P=ΣF_i/Fmax*100 %, where ΣF_i is the amount of scoring significance of each factor; F max – the maximum value of the scores of risk factors, equal to 17 points. If the value of P is from 0 to 50 %, it is concluded that the probability of survival is more than 36 months; from 51 % to 75 % – the probability of survival of 18–36 months, inclusive; more than 76 % – probability of survival less than 18 months.

EFFECT: method provides an accurate determination of survival in this group of patients.

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