METHOD OF MULTI-ORGAN PROTECTION AT CARDIAC SURGICAL INTERVENTIONS ACCOMPANIED BY CIRCULATORY ARREST Russian patent published in 2019 - IPC A61H31/00 C01B21/24 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiovascular surgery, and can be used for multi-organ protection in cardiac surgery, accompanied by circulatory arrest. NO at a dose of 40 ppm is delivered throughout the entire period of artificial blood circulation until the target core temperature is reached, the perfusion rate is reduced to 8–10 %, and the brain begins to undergo antegrade perfusion and circulatory arrest. Resumption of NO delivery at a dose of 40 ppm to the extracorporeal circulation circuit is resumed from the moment of resumption of the corporal perfusion and the beginning of the patient's warming. Stop the delivery of NO to the extracorporeal circulation circuit during period of the second parallel circulation after removal of the clamp from the aorta and the restoration of effective cardiac activity. Immediately after the patient is weaned from cardiopulmonary bypass, NO is delivered through the circuit of the ventilator at a dose of 40 ppm and this NO delivery protocol is maintained throughout the operation and during the postoperative period. Stop the flow of NO 4 hours after the intervention.

EFFECT: method provides a reduction in the number of postoperative complications in patients operated on under conditions of artificial blood circulation and circulatory arrest, as a result of blocking the pathogenetic mechanisms of organ damage in the early postoperative period.

1 cl, 1 ex