CHIMERIC ANTIGENIC RECEPTOR Russian patent published in 2019 - IPC C07K14/725 C07K19/00 C07K16/30 C12N5/783 C12N15/13 C12N15/63 A61K35/17 A61K47/66 A61K47/68 A61K47/69 A61P35/00 

FIELD: medicine.

SUBSTANCE: present invention relates to immunology. Disclosed is a chimeric antigenic receptor (CAR), which contains a disiahoganglioside (GD2)-binding domain. Also disclosed is a nucleic acid encoding a CAR of the invention; an expression vector; T-cells and a method for producing T-cells. There are also described a pharmaceutical composition, a method of treating a malignant tumour and use of T-cell in preparing a drug for treating a malignant tumour. Disclosed CAR provides increased production of INF-γ, proliferation of CAR-T-cells and destruction of neuroblastoma cells in comparison with CAR on the basis of antibody 14g2a.

EFFECT: this invention may find further application in therapy.

26 cl, 15 dwg, 10 ex