FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to endocrinology, and concerns prediction of development of type 2 diabetes mellitus in individuals residing in Bashkortostan. That is ensured by isolating DNA from lymphocytes of peripheral venous blood, performing genotyping by polymerase chain reaction of DNA synthesis and amplification of section rs2107538 of chemokine CCL5 gene and section rs6749704 of chemokine CCL20 gene. If observing the C/T or T/T genotypes of the polymorphous locus rs2107538 of the CCL5 gene or the C/C genotype of the polymorphic locus rs6749704 of the CCL20 gene, a risk of developing type 2 diabetes mellitus is predicted in the patient being tested.
EFFECT: method provides high accuracy of prediction by evaluating chemokine polymorphisms – specific inflammation markers, prognostically significant in determining the risk of developing type 2 diabetes mellitus.
1 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTING THE RISK OF DEVELOPING TYPE 2 DIABETES IN RESIDENTS OF CENTRAL RUSSIA BASED ON GENOTYPING OF THE rs11073891 POLYMORPHISM OF THE ANPEP GENE | 2023 |
|
RU2803636C1 |
| METHOD OF PREDICTING THE RISK OF DEVELOPING TYPE 2 DIABETES MELLITUS IN OBESE AND/OR PRE-DIABETIC INDIVIDUALS | 2022 |
|
RU2801174C1 |
| METHOD FOR PREDICTING THE DEVELOPMENT OF CHILDHOOD OBESITY IN THE REPUBLIC OF BASHKORTOSTAN | 2022 |
|
RU2794991C1 |
| METHOD OF PROGNOSING DEVELOPMENT OF TYPE 1 SUGAR DIABETES IN POPULATIONS OF BASHKORTOSTAN PEOPLES | 2008 |
|
RU2368325C1 |
| METHOD FOR PREDICTING CONGENITAL CLEFT LIP AND PALATE IN A CHILD WHEN PLANNING PREGNANCY IN A REGION WITH ECOTOXICANTS USING GENETIC MARKERS | 2021 |
|
RU2760786C1 |
| METHOD FOR PREDICTING CLINICAL COURSE OF DIABETES MELLITUS TYPE 1 IN BASHKORTOSTAN PEOPLE POPULATIONS | 2005 |
|
RU2285921C1 |
| METHOD FOR PREDICTION OF SEVERITY OF CLINICAL COURSE OF ACUTE PYOINFLAMMATORY DISEASES OF MAXILLOFACIAL AREA IN CHILDREN | 2012 |
|
RU2483307C1 |
| METHOD OF PREDICTING CARDIOVASCULAR COMPLICATIONS IN PATIENTS WITH ISCHEMIC HEART DISEASE | 2017 |
|
RU2670689C9 |
| METHOD OF FORECASTING OF PRIMARY ADENTIAE | 2009 |
|
RU2394242C1 |
| METHOD FOR PREDICTING EARLY DEVELOPMENT OF DUODENAL ULCER | 2016 |
|
RU2652275C2 |
