FIELD: chemistry.
SUBSTANCE: invention relates to a novel compound of formula (I) and its (R) or (S) isomers and pharmaceutically acceptable salts thereof. Compound of formula (I) is 
. Its isomers: (R)-3-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-7,8,8a,9-tetrahydropyrrolo[1',2':3,4]imidazo[1,2-c]pyrimidin-1(6H)-one corresponds to formula 
, (S)-3-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-7,8,8a,9-tetra-hydropyrrolo[1',2':3,4]imidazo[1,2-c]pyrimidin-1(6H)-one corresponds to formula 
.
EFFECT: compounds inhibit activity of lipoprotein-associated phospholipase A2 (Lp-PLA2) and can be used for treating a neurodegenerative disease, particularly Alzheimer's disease.
21 cl, 4 ex
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