FIELD: chemistry.
SUBSTANCE: invention relates to a novel compound of formula (I) and its (R) or (S) isomers and pharmaceutically acceptable salts thereof. Compound of formula (I) is 
. Its isomers: (R)-3-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-7,8,8a,9-tetrahydropyrrolo[1',2':3,4]imidazo[1,2-c]pyrimidin-1(6H)-one corresponds to formula 
, (S)-3-((3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)benzyl)oxy)-7,8,8a,9-tetra-hydropyrrolo[1',2':3,4]imidazo[1,2-c]pyrimidin-1(6H)-one corresponds to formula 
.
EFFECT: compounds inhibit activity of lipoprotein-associated phospholipase A2 (Lp-PLA2) and can be used for treating a neurodegenerative disease, particularly Alzheimer's disease.
21 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OBTAINING AND USING TRICYCLIC PYRIMIDINONE COMPOUND AND COMPOSITION THEREOF | 2021 |
|
RU2820903C1 |
| TETRACYCLIC PYRIMIDINONE COMPOUND, A METHOD OF ITS PREPARATION, AS WELL AS ITS COMPOSITION AND USE | 2020 |
|
RU2807523C1 |
| DIKETONES AND HYDROXYKETONES AS ACTIVATORS OF CATENIN SIGNALLING PATHWAY | 2011 |
|
RU2592694C2 |
| DPP-IV INHIBITORS FOR TREATMENT OF NEURODEGENERATION AND COGNITIVE DISORDERS | 2005 |
|
RU2394570C2 |
| DIPEPTIDYL KETOAMIDE META-METHOXYPHENYL DERIVATIVES AND THEIR USE | 2019 |
|
RU2787766C2 |
| COMPOUNDS AND METHODS | 2015 |
|
RU2711442C2 |
| ARYLCYCLOPROPYLAMINE BASED DEMETHYLASE INHIBITORS OF LSD1 AND THEIR MEDICAL USE | 2011 |
|
RU2611437C2 |
| TRICYCLIC JANUS KINASE 1 INHIBITORS, COMPOSITIONS, METHODS OF PRODUCTION AND USE THEREOF | 2019 |
|
RU2824349C2 |
| RAPAMYCIN DERIVATIVES | 2018 |
|
RU2807188C2 |
| GSK-3 INHIBITORS | 2006 |
|
RU2449998C2 |
