METHODS OF PURIFYING VIRUS PRODUCED IN VITRO, AND VIRUS ELIMINATION ANALYSIS Russian patent published in 2019 - IPC C12N7/00 C12N7/02 A61K39/29

Abstract RU 2691026 C1

FIELD: biotechnology.

SUBSTANCE: invention represents a method for purifying virus without shell or pseudo-shell produced in vitro using a composition with at least one detergent. Also disclosed are a purification method in which several detergents can be used, and a method for determining presence and/or level of a virus without a coat or with a pseudo-shell in a sample.

EFFECT: invention enables producing high-purity and high-titre HEV virus preparations which are suitable for use in virus elimination studies at subsequent stages of the production process.

23 cl, 4 dwg, 4 tbl, 8 ex

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RU 2 691 026 C1

Authors

Buno Brett

Journigan Terri

Hotta Joann

Burdick Michael

Dates

2019-06-07—Published

2016-07-15—Filed