COMPOUNDS FOR PREVENTING AND TREATING NEURODEGENERATIVE DISEASES AND PAIN Russian patent published in 2019 - IPC C07D498/02 C07D515/02 A61K31/7076 A61P25/16 

FIELD: medicine.

SUBSTANCE: present invention refers to a compound for treating neurodegenerative diseases and pain, a method for preparing it and compositions based thereon. Disclosed is a compound having the following structure:

or its pharmaceutically acceptable salt, where X is Cl or Br. Disclosed method comprises a step of reacting 6-chloropurinurbofuranoside in the presence of a base with an appropriately substituted (thienyl)methanamine, or first obtaining (2',3'-O-isopropylidene) adenosine derivative containing a hydroxyl-protecting group, then obtaining (2',3'-O-isopropylidene) adenosine derivative containing a hydroxyl-protecting group and an amino-protecting group which is reacted with the corresponding thienyl derivative 7:

,

where X is Cl or Br and Y is X, OH, methanesulfonate (OSO₂CH₃, OMs), p-toluenesulfonate (OSO₂C₆H₄-p-CH₃, OTs), or trifluoromethanesulfonate (OSO₂CF₃, OTf), after which protective groups are removed.

EFFECT: novel compounds effective in treating neurodegenerative diseases and pain, effective methods for preparing them and compositions based thereon.

17 cl, 7 ex, 10 dwg