FIELD: chemistry.
SUBSTANCE: invention relates to a novel method of synthesis of 2,5-diketomorpholines. Use of penicillin acylase enzyme at the stage of formation of amide bond enables high output and high enantiomeric purity of the end product.
EFFECT: novel method of producing 2,5-diketomorpholines, which involves a biocatalytic stage of formation of an amide bond between a carboxyl group of an oxyacid and an amino group of an amino acid with a subsequent chemical step of intramolecular esterification.
6 cl, 6 ex
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