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2 709 833

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IPC

A61M5/32(2006-01-01)

A61K38/14(2006-01-01)

A61P15/00(2006-01-01)

G09B23/28(2006-01-01)

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Application

2019118254, 2019-06-13

(24)

Start date

2019-06-13

(22)

Actual filing date

2019-06-13

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Published

2019-12-23

(72)

Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichLokteva Tatyana IvanovnaAntsiferova Oksana EvgenevnaYurakova Alesya ViktorovnaPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaZhilinkova Lyudmila AnatolevnaZatolokina Mariya AlekseevnaShchurovskaya Kristina VladimirovnaKolesnichenko Pavel DmitrievichPakhomov Sergej PetrovichSeverinova Olga VladimirovnaGolubev Ivan VladimirovichIvakhno Elena NikolaevnaPovetka Elena EvgenevnaGureeva Anastasiya VladimirovnaVajn Darya SergeevnaMurashev Boris VladimirovichProshin Anton Yurevich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD OF PLACENTAL MICROCIRCULATION CORRECTION BY ASIALIZED ERYTHROPOIETIN IN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2019 - IPC A61M5/32 A61K38/14 A61P15/00 G09B23/28

Abstract RU 2709833 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely experimental pharmacology, and can be used for correction of placental microcirculation in ADMA-like model of preeclampsia. That is ensured by reproducing a model of preeclampsia in Wistar rats by daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg from 14th to 20th day of pregnancy. That is combined with administration of asialized erythropoietin subcutaneously in dose of 2.4 mcg/kg once day from 10th to 20th day of pregnancy to correct the simulated pathology.

EFFECT: method provides pronounced correction of microcirculation in placenta in simulated pathology due to pronounced anti-ischemic and antioxidant action of administered asialized erythropoietin.

1 cl, 1 tbl, 1 ex

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RU 2 709 833 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Lokteva Tatyana Ivanovna

Antsiferova Oksana Evgenevna

Yurakova Alesya Viktorovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Murashev Boris Vladimirovich

Proshin Anton Yurevich

Dates

2019-12-23—Published

2019-06-13—Filed