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2 735 766

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IPC

G09B23/28(2006-01-01)

A61K31/44(2006-01-01)

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Application

2020118164, 2020-06-02

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Start date

2020-06-02

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Actual filing date

2020-06-02

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Published

2020-11-06

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Inventor

Gureev Vladimir VladimirovichPokrovskij Mikhail VladimirovichYurakova Alesya ViktorovnaGolubev Ivan VladimirovichPokrovskaya Tatyana GrigorevnaPeresypkina Anna AleksandrovnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichPobeda Anna SergeevnaYakushev Vladimir IvanovichKorokina Liliya ViktorovnaLazareva Galina AnatolevnaGureeva Elena GennadievnaChernomortseva Elena StanislavovnaKonovalova Elena AnatolevnaZatolokina Mariya AlekseevnaZhunusov Nikita Sergeevich

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Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR CORRECTION OF PLACENTAL MICROCIRCULATION DISORDER WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN ADMA-LIKE MODEL OF PREECLAMPSIA Russian patent published in 2020 - IPC G09B23/28 A61K31/44

Abstract RU 2735766 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental microcirculation disorders. Method of correction of placental microcirculation disturbance in ADMA-like model of preeclampsia includes reproduction of preeclampsia model in Wistar rats due daily from 14th to 20th day of pregnancy intraperitoneal introduction of L-nitro-arginine-methyl ether in dose of 25 mg/kg, wherein the simulated pathology is corrected by introducing 3-hydroxy-2-ethyl-6-methylpyridinium nicotinate substance in amount of 260 mg/kg intraperitoneally from 14th to 20th day of pregnancy.

EFFECT: invention provides pronounced correction of placental microcirculation disturbance.

1 cl, 1 ex, 1 tbl

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RU 2 735 766 C1

Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Yurakova Alesya Viktorovna

Golubev Ivan Vladimirovich

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Yakushev Vladimir Ivanovich

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Chernomortseva Elena Stanislavovna

Konovalova Elena Anatolevna

Zatolokina Mariya Alekseevna

Zhunusov Nikita Sergeevich

Dates

2020-11-06—Published

2020-06-02—Filed