FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental microcirculation disorders. That is ensured by daily intraperitoneal introduction of L-nitro-arginine-methyl ether in laboratory pregnant Wistar rats in the pre-eclampsia simulation on 14th–20th day of pregnancy in dose of 25 mg/kg to correct simulated pathology, intragastric methyl ester of (2-((2-hydroxyphenyl)thio)acetyl)-L-proline sodium salt of (2-((2-hydroxyphenyl)thio)acetyl)-D-proline in dosage 1 mg/kg/day once per day from 14 to 20 days of pregnancy.
EFFECT: invention provides pronounced correction of placental microcirculation disturbance in conditions of reproduced ADMA-like model of preeclampsia.
1 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
RU2727572C1 |
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|
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|
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| METHOD OF CORRECTING ENDOTHELIAL DYSFUNCTION WITH TRIMETAZIDINE IN AN ADMA-LIKE MODEL OF PREECLAMPSIA | 2018 |
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RU2700563C1 |
| METHOD OF ENDOTHELIAL DYSFUNCTION CORRECTION IN ADMA-LIKE MODEL OF PREECLAMPSIA USING DETRALEX | 2019 |
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| METHOD FOR CORRECTING ENDOTHELIAL DYSFUNCTION WITH SUBSTANCE OF 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN AN ADMA-LIKE MODEL OF PREECLAMPSIA | 2020 |
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RU2735903C1 |
