FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental microcirculation disorders. A method of correcting microcirculation disorders in the placenta in an ADMA-like pre-eclampsia model involves reproducing a pre-eclampsia model in the Wistar rats daily from 14 to 20 day of pregnancy by intraperitoneal administration of L-nitro-arginine-methyl ester 25 mg/kg, correction of simulated pathology by intragastric detrox administration in dosage of 86 mg/kg once day from 14 to 20 days of pregnancy or in dosage of 260 mg/kg once day from 14 to 20 days of pregnancy.
EFFECT: invention provides pronounced correction of microcirculation in simulated pathology.
1 cl, 1 ex, 1 tbl
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