METHOD OF CORRECTION OF PLACENTAL MICROCIRCULATION DISORDERS WITH USING DETRALEX Russian patent published in 2020 - IPC G09B23/28 A61K31/7048 A61P15/06 

Abstract RU 2727572 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to experimental pharmacology, and can be used for correction of placental microcirculation disorders. A method of correcting microcirculation disorders in the placenta in an ADMA-like pre-eclampsia model involves reproducing a pre-eclampsia model in the Wistar rats daily from 14 to 20 day of pregnancy by intraperitoneal administration of L-nitro-arginine-methyl ester 25 mg/kg, correction of simulated pathology by intragastric detrox administration in dosage of 86 mg/kg once day from 14 to 20 days of pregnancy or in dosage of 260 mg/kg once day from 14 to 20 days of pregnancy.

EFFECT: invention provides pronounced correction of microcirculation in simulated pathology.

1 cl, 1 ex, 1 tbl

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Authors

Gureev Vladimir Vladimirovich

Pokrovskij Mikhail Vladimirovich

Lokteva Tatyana Ivanovna

Antsiferova Oksana Evgenevna

Yurakova Alesya Viktorovna

Pokrovskaya Tatyana Grigorevna

Peresypkina Anna Aleksandrovna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Pobeda Anna Sergeevna

Korokina Liliya Viktorovna

Lazareva Galina Anatolevna

Gureeva Elena Gennadievna

Zhilinkova Lyudmila Anatolevna

Zatolokina Mariya Alekseevna

Shchurovskaya Kristina Vladimirovna

Kolesnichenko Pavel Dmitrievich

Pakhomov Sergej Petrovich

Severinova Olga Vladimirovna

Golubev Ivan Vladimirovich

Ivakhno Elena Nikolaevna

Povetka Elena Evgenevna

Gureeva Anastasiya Vladimirovna

Vajn Darya Sergeevna

Kudryavtsev Konstantin Viktorovich

Yakushev Vladimir Ivanovich

Dates

2020-07-22Published

2019-12-03Filed