FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and molecular biology. Described are mitochondrial localization signal peptides (sequences are presented in Table 1: SEQ ID 1, SEQ ID 2, SEQ ID 3, SEQ ID 4, SEQ ID 5, SEQ ID 6, SEQ ID 7, SEQ ID 8, SEQ ID 9, SEQ ID 10). When using said peptides in a fused polypeptide chain with target recombinant proteins, the level of output of the target recombinant proteins increases, the quality of folding of said proteins with their expression using yeast-based producer strains, particularly P. pastoris and S. cerevisiae.
EFFECT: invention can be used to increase level of output of recombinant proteins and change of quality of their folding at their expression using yeast based producer strains, in particular Pichia pastoris and Saccharomyces cerevisiae.
1 cl, 2 tbl
