FIELD: biotechnologies.
SUBSTANCE: invention relates to the biotechnology. Described are methods for modulating expression of target nucleic acid in a cell, involving use of a plurality of orthogonal Cas9 proteins in order to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
EFFECT: invention extends the range of agents aimed at activating gene expression.
24 cl, 17 dwg, 1 tbl, 20 ex
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