FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to a method of selecting a stable antibody producing under the control of a CMV promoter of a human with SEQ ID NO: 1 Chinese hamster ovary CHO-K1 cells.
EFFECT: disclosed method of selecting antibody-producing cells based on determination of histone 3 acetylation level and cpG-site methylation frequency in position 425 in SEQ ID NO: 1 enables reducing the number of clones to be tested during cultivation of several generations.
7 cl, 28 dwg, 20 tbl, 13 ex
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