FIELD: medicine.
SUBSTANCE: invention relates to medicine. That is ensured by administering a therapeutically effective amount of at least one recombinant alkaline phosphatase having the sequence SEQ ID NO: 1, wherein the subject is insensitive to the treatment of convulsions with vitamin B6.
EFFECT: invention refers to treating convulsions in a human subject having abnormal levels of at least one substrate of alkaline phosphatase selected from pyridoxal-5'-phosphate (PLP), inorganic pyrophosphate (PPi) and phosphoethanolamine (PEA).
29 cl, 14 dwg, 5 tbl, 7 ex
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