NOVEL EUKARYOTIC CELLS AND METHODS FOR PREPARING THEREOF FOR RECOMBINANT EXPRESSION OF PRODUCT OF INTEREST Russian patent published in 2020 - IPC C07K16/00 C12N5/00 C12P21/00

Abstract RU 2712507 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to novel eukaryotic cells suitable for recombinant production of a product of interest, where host cell genome is modified to inhibit FAM60A protein function in said cell, for example, by reducing or blocking functional expression of FAM60A gene, which increases its stability. Besides, the present invention relates to technologies of recombinant production, in which such host cells are used.

EFFECT: invention provides higher level of polypeptide production.

17 cl, 9 dwg, 12 tbl, 6 ex

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RU 2 712 507 C2

Authors

Dzhostok Tomas

Lauks Kholger

Ritter Anett

Dates

2020-01-29—Published

2014-12-18—Filed