FIELD: biotechnology.
SUBSTANCE: invention relates to a method of producing Gd3+-binding protein. Protein complex with Gd3+ ions, in turn, can be used to produce a physiologically acceptable Gd3+-containing agent suitable for contrasting tumors by paramagnetic resonance spectroscopy and radiotherapy of tumors by the principle of thermal ablation.
EFFECT: technical result of this invention is a method of producing Gd3+-binding ligand based on artificial recombinant protein, having the ability to firmly hold a metal ion in conditions close to physiological, providing its detoxification and targeted delivery to tumor tissue.
3 cl, 7 dwg, 2 ex
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