COVALENT CONJUGATES BASED ON PHTHALOCYANINES AND METHYLPHEOPHORBIDE A, METHODS FOR PREPARE AND USE THEREOF IN MEDICINE Russian patent published in 2020 - IPC C08K5/3467 

Abstract RU 2722309 C1

FIELD: chemistry.

SUBSTANCE: invention refers to conjugates based on macroheterocycles of tetrapyrrolic type, which can be used in theranostics, a modern direction in medicine combining therapy and diagnostics of oncological diseases. Described is a conjugate of general formula (I):

where X = O, -OCH2C6H4CH2O-; M = Mg, Zn, AlCl; Y = Y' = H, lower alkyl; Y ≠ Y': Y = H, Y' = lower alkyl, OH, - OCH2C6H4CH2OH, pheo, -OCH2C6H4CH2(pheo). Method of producing the conjugate and use thereof are also described.

EFFECT: technical result is improved photophysical properties of the conjugate.

9 cl, 6 dwg, 1 tbl

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RU 2 722 309 C1

Authors

Tomilova Larisa Godvigovna

Pushkarev Viktor Evgenevich

Balashova Irina Olegovna

Shestov Vladimir Ilich

Ponomarev Gelij Vasilevich

Kojfman Oskar Iosifovich

Platonova Yana Borisovna

Volov Aleksandr Nikolaevich

Dates

2020-05-28Published

2019-03-25Filed