FIELD: biochemistry.
SUBSTANCE: invention relates to a genetically modified mouse which expresses a SIRPα protein human and human IL-15 protein, as well as to a method for production thereof. Also disclosed is a method of engraftment of human hematopoietic cells of said genetically modified mouse. Invention also relates to a method for identifying an agent which suppresses a pathogen infection, as well as to a method for determining the efficacy of a potential therapeutic antibody or antigen-binding protein in a NC cell-mediated destruction of a target cell using the above mouse.
EFFECT: invention makes it possible to effectively model the development and functioning of human natural killer cells (NC).
46 cl, 25 dwg, 1 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMANIZED MICE WITH SIRPA-IL15 KNOCKIN AND METHODS OF USE THEREOF | 2016 |
|
RU2822370C2 |
| NON-HUMAN GENETICALLY MODIFIED ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2711744C1 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO | 2015 |
|
RU2799086C2 |
| NON-HUMAN ANIMALS HAVING HUMANIZED SIGNAL-REGULATORY PROTEIN GENE | 2014 |
|
RU2671166C2 |
| GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS FOR USE THEREOF | 2013 |
|
RU2673156C2 |
| HUMANISED IL-15 ANIMALS | 2014 |
|
RU2674910C2 |
| ANIMALS OTHER THAN HUMANS HAVING A HUMANISED CLUSTER GENE OF DIFFERENTIATION 47 | 2015 |
|
RU2728412C2 |
| NON-HUMAN ANIMALS HAVING HUMANIZED Fc-γ-RECEPTORS | 2015 |
|
RU2700484C2 |
| HUMANIZED IL-7 RODENTS | 2013 |
|
RU2654565C2 |
| ANIMALS WITH HUMANIZED IL-4 AND IL-4Rα | 2015 |
|
RU2703139C2 |
