METHOD OF PRODUCING 12-CYCLOALKYL-12,13,13B,13C-TETRAHYDRO-6H,11H,14H-4B,5A,10B,12,13A-PENTAAZADIBENZO[A,H]CYCLOHEPTA[1,2,3,4-DEF]FLUORENES Russian patent published in 2020 - IPC C07D487/22 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 12-cycloalkyl-12,13,13b,13c-tetrahydro-6H,11H,14H-4b,5a,10b,12,13a-pentaazadibenzo[a,h]cyclohepta[1,2,3,4-def]fluorenes of general formula (1). Method comprises reacting corresponding alkylamines of RNH₂ with a paraform in a medium of CH₃OH at temperature of 60 °C for 1 hour with subsequent addition to obtained reaction mixture at 20 °C catalyst NiCl₂⋅6H₂O and 1,1',2,2',3,3',4,4'-octahydro-2,2'-benzo-quinazoline in DMSO medium in molar ratio of cycloalkylamine: paraform: octahydro-biquinazoline: NiCl₂⋅6H₂O = 3:3:1:(0.03–0.07) and further stirring at temperature of 20 °C and atmospheric pressure for 2.5–3.5 hours

EFFECT: obtained according to the method of the compound of formula (1) can have fungicidal and insecticidal activity, as well as anti-inflammatory, antibacterial and antineoplastic properties.

1 cl, 1 tbl, 2 ex